Step 1 : Head to theColorado Riverand look for an slimy European olive tree - colored frog . Step 2 : “ Milk River ” the toad frog ’s skin for a slimy white venom and dry it out . gradation 3 : Smoke it .

This might not fathom like the most clinical advance to genial well - being , but new grounds indicate that psychedelic anuran slime could really hold some really wakeless benefits for genial   health .

Published in the September 2019 issue of the journalPsychopharmacology , a novel study has set up that just one inhalation of vapor produced from desiccated toad frog secernment is associated with a   free burning atonement with life and a step-down in level of anxiety , tenseness , and depression .

The toad is known as theColorado River toador the Sonoran Desert toad and , as the name suggests , it can be found in parts of   northern Mexico and the southwestern US . As part of its defense against predators , the toad secrete a toxic substance from a number of glands across its leathery consistence .

The toxic secretion also contains 5 - methoxy - N , N - dimethyltryptamine , a psychedelic substance with a similar structure to DMT , come up in the mind - alter psychedelic brewayahuasca . If the liquid is dry out into a crystallized powder and then smoked , it creates an intense psychedelic slip within second of inhalation . As designate by itsdepictions in Mesoamerican art , this drug has been used for spiritual purposes for centuries and it ’s still widely look at today   as a treatment for genial wellness problems or as a agency for ghostlike exploration .

For this study , investigator from Maastricht University in the Netherlands and the University of Chemistry and Technology in Czechia assessed the experience of toad spitefulness smoking among 42 people recruit from Czechia , Spain , and the Netherlands . All of the player , who took a individual intake of the heart and soul in a “ naturalistic scene , ” were quizzed about their mindset , noesis , and humour within 24 hours of the trip-up and then once more after four week .

The findings showed that most participants experienced substantial declines in feeling of clinical depression , anxiety , and tension following the trip-up . One calendar month on , this effect appeared to have become even more profound .

“ A unmarried aspiration of vaporization from dried toad secernment containing 5 - MeO - DMT produces sub - acute and long - condition changes in affect and cognition in military volunteer , ” the researchers write .

“ Participants that experienced high-pitched levels of ego profligacy or ' oceanic unboundedness ' during the sitting display higher ratings of satisfaction with life and depressed rating of Great Depression and stress . ”

However , there are a few things to believe when draw conclusions from this study . The research started off with 75 participants , but only 42 came back for the follow - up investigation . This has the potential to skew the termination in a numeral of ways . For case , it ’s fair to suggest that participants who came back for the follow - up perhaps had a more positive experience with the drug than those who did n’t . Despite these shortcoming , the research put up some fertile terra firma for further probe .

“ These results warrant exploratory inquiry into therapeutic lotion of 5 - MeO - DMT , ” the inquiry team tote up .