Christina Applegate and Edie Falco.Photo:Getty (2)

Christina Applegate; edie falco

Getty (2)

Edie Falcosays she sometimes mourns the end of her time parenting little kids.

“Nobody talks about when those little kids disappear – it’s like a death,” says Falco, 60, whose son, Anderson, is 19 and whose daughter, Macy, is 16.

Falco swaps parenting stories and more alongside herSopranosstarJamie-Lynn Sigler,on the second episode ofMeSsy, Sigler’s new podcast withChristina Applegate, PEOPLE has an exclusive preview of the podcast episode before it comes out March 26.

The second episode of Applegate and Sigler’s MeSsy podcast is out March 26.Wishbone Production

MeSsy podcast promo art

Wishbone Production

Jamie-Lynn Sigler and Christina Applegate, photographed for PEOPLE March 6, 2024.John Russo

Christina Applegate and Jamie-Lynn Sigler photographed exclusively by John Russo in the Hollywood Hills on March 6, 2024.

John Russo

Jamie-Lynn Sigler, husband Cutter Dykstra and sons Jack and Beau.Courtesy Jamie-Lynn Sigler

Jamie-Lynn Sigler

Courtesy Jamie-Lynn Sigler

Adds Applegate, whose daughter Sadie is 13, “To know we’re not going to get that back freaks me out.'"

Edie Falco with son Anderson and daughter Macy in 2011.Amanda Schwab/Startraksphoto.com/Instar

Edie Falco with son Anderson Falco and daughter Macy Falco

Amanda Schwab/Startraksphoto.com/Instar

Applegate, who’s admitted that living with multiple sclerosis haschanged how she can parent, jokes that she wants to keep her daughter as close as possible, as long as possible: “I told Sadie when she goes to college, wherever it is, I’ll be moving in with her. I highly encourage Los Angeles-based universities. I’m like, ‘Why would you live in a dorm when we have our nice house?’ I’m doing everything I can to make her stay here.”

Christina Applegate and daughter Sadie, at the Emmy Awards January 2024.Jordan Strauss/Invision for the Television Academy/AP Images

Christina Applegate, left, and Sadie Grace LeNoble at the 75th Emmy Awards on Monday, Jan. 15, 2024 at the Peacock Theater in Los Angeles.

Jordan Strauss/Invision for the Television Academy/AP Images

Applegate and SIgler started the podcast, which debuted March 19, after their mutual friendLance Bassencouraged them to connect because of their shared MS diagnoses. “We’d talk on the phone for hours, laughing and crying,” theDead to Mestar told PEOPLE of her friendship with Sigler. “And then we were like, ‘This is helping us. Let’s record this.'”

Applegate and Sigler photographed for PEOPLE March 2024.John Russo

Christina Applegate and Jamie-Lynn Sigler photographed exclusively by John Russo in the Hollywood Hills on March 6, 2024.

The two also bonded over the fact that they both struggled with health issues while they were filmingThe Sopranos. Sigler hid the fact that she had been diagnosed with MS, while Falco was quietly being treated for breast cancer. But in both cases, Sigler says, their co-starJames Gandolfiniknew something was wrong — and they each confided in him.

Jamie-Lynn Sigler, James Gandolfini, Edie Falco and Robert Iler on the set of The Sopranos in 1999.HBO/Courtesy Everett Collection

SOPRANOS, Jamie Lynn Sigler, James Gandolfini, Edie Falco, Robert Iler, ‘Pax Soprana’

HBO/Courtesy Everett Collection

“They were calling in acting coaches to the set for me because I could’t tell anybody what was wrong but people could tell something was wrong,” Sigler said. To Falco, she said, “I’m so sorry when you were going through breast cancer, and that a lot of it was quietly. You said Jim called you out and said something is up. He did the same thing to me. He pulled me aside one day and said, ‘Something is wrong and you’re not telling anybody,’ and in that moment I told him.”

source: people.com